Atherosclerosis and osteoporosis were the most common illnesses of older people,which seriously affected the health of the elderly,and the two diseases often appeared simultaneously in clinical.Atherosclerosis,hypertension,diabetes,vascular injury,chronic kidney disease and pathological aging and so on had the common pathology of vascular calcification.It easily led to myocardial ischemia,left ventricular hypertrophy and heart failure,caused thrombosis,plaque rupture,so it was an important factor for the high incidence and high mortality of cardiovascual and cerebrovascular diseases.Recently many studies suggested that there were the common risk factors,signal transduction pathways,molecular mechanism,leading to causality among atherosclerosis,vascular calcification and osteoporosis.This review on the link between clinical and pathogenesis of preliminary study for clinical work,provides further integrated control concept.