Aim To study the effect of blood flow on life qualifty in hemodialysis patients with more than five years of permanent vascular access.Methods 88 hemodialysis patients with more than five years of permanent vascular access were selected and divided into experimental group(blood flow of vascular access ≤ 300 mL/min,n=45) and control group(blood flow of vascular access was 300~500 mL/min,n=43).Patients in the experimental group and the control group were treated with conventional dialysis,and the complications,Hb,BUN,Scr,ALB,RRF and other factors affecting life quality were analyzed.Results After dialysis,BUN and Scr levels in the experimental group were higher than those in the control group(24.87±7.97 mmol/L and 675±232 μmol/L vs 17.34±9.53 mmol/L and 368±243 μmol/L;P<0.05),Hb levels in the experimental group were lower than those in the control group(70.62±12.03 g/L vs 76.03±13.05 g/L;P<0.05),ALB levels had no significant difference in the two groups(P>0.05).RRF in the experimental group reduced 90.9%,significantly higher than 36.4% of control group.The chance of restenosis and blood flow during reperfusion in the experimental group were significantly worse than those in the control group(P<0.05).Conclusions Patients with permanent vascular access for dialysis and vascular access blood flow ≤ 300 mL/min should pay attention to changes in bodily functions in the dialysis process.Dialysis program should be adjusted at the appropriate time by increasing dialysis frequency and prevention of complications to improve life quality.