AimTo study the effect of angiotensin(1-7) on inhibiting the inflammation induced by angiotensinⅡ （AngⅡ）.MethodsCultured human umbilical vein endothelial cells(HUVEC) were randomly dividied into different groups ,then incubated in the presence of Ang(1-7), AngⅡ and the specific inhibitor of Ang(1-7), A-779, and so on. The phosphorylation of p38MAPK were determined by Western blot, and the mRNA for the mas receptor were determined by reverse transcriptional PCR.ResultsAng(1-7) dose-dependently inhibited the phosphorylation of p38MAPK induced by AngⅡ in HUVECs. The expression of p38MAPK phosphorylation died down markedly at 1 000 nmol/L of Ang(1-7). Pre-treatment with A-779 for 10 min in HUVEC before Ang(1-7) and AngⅡ used, the expression of p38 MAPK phosphorylation was nonsignificantly changed.ConclusionAng(1-7) effectively represses the phosphorylation of p38MAPK induced by AngⅡ in HUVEC.