Vascular remodeling of ischemic disease rely on not only angiogenesis, but also bone marrow precursor cells and many growth factors， such as vascular endothelial growth factor and platelet-derived growth factor.Ischemia itself can not only increase the number of stem cells, but also enhance their ability for differentiation to endothelial cells.however, ischemia- induced vascular remodeling often cannot completely supply blood decrease of peripheral vascular disease and arterial occlusion.So, to promote blood recovery of ischemic tissues, growth factors are used to mobilize vascular precursor cells and enhance angiogenesis.Synergistic effects of cytokines on neovascularization are reviewed in this paper.