Aim To investigate the combined therapeutic effects of statins(atorvastatin) and angiotensin receptor blocker(ARB,valsartan) for six months on patients with coronary borderline lesions confirmed by 64-row multi-detector computed tomography(MDCT),with emphasis on systemic inflammatory response and imaging characteristics of coronary plaques. Methods 116 patients with borderline coronary lesions detected by MDCT were enrolled and divided into two groups: single-treatment group(56 patients) and combined-treatment group(60 patients).In single treatment group,patients were received atorvastatin,and patients of combined-treatment group were treated with atorvastatin and valsartan.Plasma high sensitive C-reaction protein(hs-CRP) and brain natriuretic peptide(BNP) were examined before and after treatment in each group,and coronary artery lesions was rechecked by MDCT to evaluate the change of coronary artery plaques after six months of treatment. Results Significant decreases were observed in plasma hs-CRP and BNP after treatment in both groups(P><0.01),and patients in combined-treatment group exhibited more significant decreases than single-treatment group(P><0.05).Left ventricular ejection fractions(LVEF) in all patients were significantly elevated(P><0.01),and patients of combined-treatment group showed more significant improvement than single-treatment group(P><0.05).In addition,MDCT showed a significant reduction of lipid plaque volume and only a slight reduction in both fibrous plaque volume and mixed plaque volume after treatment(P><0.05),and patients in combined-treatment group exhibited more significant decreases than single-treatment group(P><0.05).However,there was no significant change in calcified plaque of both groups.Incidence of adverse cardiovascular events in combind-treatment group was significantly lower than single-treatment group. Conclusion Combination of statins and ARB for six months can significantly inhibit systemic inflammatory response and stabilize coronary plaques.