Aim To investigate the changes of urine protein in patients with chronic glomerulonephritis after different doses of irbesartan treatment and find out whether there was a higher efficacy of high dose irbesartan. Methods 32 chronic glomerulonephritis patients were randomly and equally divided into normal dose group(oral irbesartan 0.15 g/d,n=16) and high dose group(oral irbesartan 0.3 g/d,n=16).Eight weeks later,24 h urine protein and serum potassium were measured. Results 24 h urine protein decreased by 40% in normal dose group and 63% in high dose group,while serum potassium had not changed in both groups. Conclusion High dose irbesartan in reducing urine protein in patients with chronic glomerulonephritis would be more marked,and the patient tolerance,from sexual health are good.