Aim To study the clinical value of interferon-γ,interleukin-10 and CRP in acute coronary syndrome. Methods Using a high sensitivity multiplex assay,previously untested in the context of atherosclerotic disease,we determined plasma concentrations of interferon-γ,interleukin-10,CRP,interleukin-2,interleukin-6,interleukin-8,TNF-α,interleukin-1β,interleukin-12p70 and GM-CSF in 68 acute myocardial infarction(AMI) patients,28 unstable angina(UA) patients and 22 healthy controls. Results Interferon-γ and CRP levels were significantly higher in AMI compared to UA group(P><0.05) and control group(P><0.05).Interleukin-10 also showed higher expression levels in AMI group compared to UA group and control group(P><0.05). Conclusion This up-regulation may reflect the extent of plaque instability and/or rupture in MI patients.Our observations provide evidence that interferon-γ,interleukin-10 and CRP merit further investigation in atherosclerotic disease states as potential markers of disease and therapeutic targets.