Aim To explore the disposition of plasma NT-proBNP level in the community cohort. Methods 734 subjects with high risks of cardiovascular diseases in Beijing Shougang community were investigated.The plasma NT-proBNP level were measured with the automated electrochemiluminescence immunoassay.Their history of myocardial infarction,angina pectoris,hypertension,atrial fibrillation,and diabetes mellitus were collected,their cardiac function were also evaluated with New York Heart Association functional classification.The left ventricular ejection fraction(LVEF) were measured by Echocardiography.To the normal LVEF subjects,they were put in different diastolic heart function groups(the normal one,the mild-damaged and the moderate/severe damaged ones) according to mitral inflow,annulus of mitral valve tissues and pulmonary venous flow of echocardiography.Then the disposition of plasma NT-proBNP level in the community cohort were analyzed. Results The percentage of NYHA functional class Ⅰ and class Ⅱ were 86.5% and 12.9%,and LVEF less than 50% was 3.5%.The median of plasma NT-proBNP level was 69.75 ng/L.The plasma NT-proBNP level in the group with coronary artery disease was higher than that in the group without coronary artery disease(108.60 ng/L vs 65.68 ng/L,P><0.05),the plasma NT-proBNP level in the group with hypertension was higher than that in the group without hypertension(72.71 ng/L vs 61.51 ng/L,P><0.05),the plasma NT-proBNP level in the group with atrial fibrillation was higher than that in the group without atrial fibrillation(93.31 ng/L vs 67.61 ng/L,P><0.05),and the plasma NT-proBNP level in the group with diabetes mellitus was higher than that in the group without diabetes mellitus(80.05 ng/L vs 66.04 ng/L,P><0.05).It was found that the plasma NT-proBNP level in the group of NYHA functional class Ⅱ was higher than that in the group of class Ⅰ(115.5 ng/L vs 65.01 ng/L,P><0.05),and the plasma NT-proBNP level in the lower LVEF group was higher than that in the normal LVEF group(293.8 ng/L vs 67.85 ng/L,P><0.05).In the group with normal LVEF,the plasma NT-proBNP level in the group with different diastolic heart function were 53.73 ng/L,75.07 ng/L,101.85 ng/L and 269.75 ng/L. Conclusion Although the plasma NT-proBNP level in the community cohort is low,but it may be a biochemical marker to monitor the change of their heart function which results in various kinds of cardiovascular diseases.