Aim To assess whether levels of serum soluble lectin-like oxidized low-density lipoprotein receptor-1(sLOX-1) are correlated with angiographic coronary lesion complexity in patients with stable angina pectoris(SAP),and evaluate the value of sLOX-1 in early prediction of the vulnerable coronary atherosclerotic plaque. Methods Levels of sLOX-1 were measured in 108 stable angina pectoris patients(46 with simple coronary lesions and 62 with complex coronary lesions).Coronary lesions were classified as of simple or complex appearance.Gensini score system was used to measure the severity of coronary artery disease;Enzyme-linked immunosorbent assay(ELISA)was used to measure sLOX-1 levels. Results sLOX-1 levels were significantly higher in stable angina pectoris patients with complex coronary lesions1.12(0.34～1.68) μg/L,n=62] than those with simple lesions 0.28(0.14～0.64) μg/L,n=46](P><0.05).Polytomous Logistic regression analysis demonstrated that serum sLOX-1 level was independently associated with complex lesions(odds ratio 2.99,95%confidence interval 1.47 to 6.08,P>=0.003).Pearman correlation analysis showed a positive correlation between log(sLOX-1) and log(Gensini Score)(correlation coefficient=0.458,P><0.05).1.10 μg/L is the critical value of serum sLOX-1 in the diagnosis of stable angina with sensitivity of 54.8% and specificity of 93.5%(P><0.05). Conclusion Serum sLOX-1 level is related to coronary lesion complexity in patients with stable angina pectoris which may be an independent risk factor for prediction of coronary plaque vulnerability and rupture.