Aim To access the effect and mechanisms of baicalin on expression of nuclear factor-κB(NF-κB)and monocyte chemoattractant protein-1(MCP-1) in experimental atherosclerotic rat. Methods High fat forage and vitamin D3 was given by intragastric administration,the experimental group was given baicalein solution 20 mg/(kg·d) for four weeks.The blood lipid,plasma MCP-1 and immunohistochemistry detection of NF-κB on the renal glomerulus was performed. Results The total cholesterol(TC) and low density lipoprotein cholesterol(LDLC) in the serum of rats decreased in the experimental group to 30% baseline values treated by baicalein.The hyperlipidemia markedly raised the activities and contents of MCP-1 in plasma after modeling.Renal interstitium was hyperemic,the glomerular volume became extension,and NF-κB was markedly expressed in the podocyte and tubular epithelial cells than that of the control group(P><0.01). Conclusion Baicalein has the function of reducing the levels of LDL,reducing the NF-κB activating in glomerular cells,reducing the performance of MCP-1,and adjusting blood fat disorders and antiinflammatory.