Aim To investigate the role of integrin-linked kinase(ILK) during progressive heart dysfunction after acute myocardial infarction(AMI),and observe the changes of heart function as well as ILK expression at different time points after AMI. Methods Left anterior descending arteries of adult male SD rats were ligated to form AMI models.Cardiac function was evaluated by echocardiography and left ventricular catheter.Real time PCR and Western blotting were used to assess ILK expression in non-infarct area.The above parameters were examined in different time points after post AMI. Results After AMI,heart function was significantly decreased.Lower of ±dp/dtmax and higher left ventricular end diastolic pressure(LVEDP) of 8 weeks group was observed,compared with 1 and 4 weeks groups post AMI.On the other hand,ILK expression of non-infarct area was increased in 1 and 4 weeks groups and decreased significantly in 8 weeks group post AMI. Conclusion Although temporary ILK up-expression in non-infarct area post acute myocardial infarction maintains compensatory cardiac function,long-term down-regulation of ILK pathway finally lead to cardiac decompensation.