Aim To explore the relationship between lipoprotein-associated phospholipase A2(LP-PLA2)gene A379V polymorphisms and coronary heart disease(CHD)by Meta-analysis.Methods PubMed,Elsevier SDOS,Vip Chinese Periodical Database,Wanfang Chinese Periodical Database and Chinese Bio-medicine Database were searched for the case-control study on the association of LP-PLA2 gene A379V polymorphisms with CHD.All articles were strictly evaluated and screened according to inclusion criteria,and meta-analysis were perfomed for the included articles using RevMan 5.0 and Stata 10.0 software.Results Seven case-control studies involving 6 718 patients with CHD and 3 824 controls were included.The results of meta-analysis showed that there was not a significant difference bewteen CHD patients carrying VV/AA and VA/AA of LP-PLA2 gene A379V and controls(P>0.05),the pooled OR(95%CI)respectively were 0.98(0.66～1.46)and 0.98(0.89～1.07).The results of subgroup meta-analysis according to the race showed that the significant differences were not found in the Asian and the European subgroup(P>0.05),the pooled OR(95%CI)of VV/AA of LP-PLA2 gene A379V in the Asian and European subgroup respectively were 1.15(0.50～2.61)and 0.89(0.68～1.17),the pooled OR(95%CI)of VA/AA respectively were 1.11(0.96～1.27)and 0.88(0.66～1.18).Conclusion More evidence is needed to prove the relationship between LP-PLA2 gene A379V polymorphisms and CHD.