Aim To explore the impact of multifactorial intervention on incidence of subclinical atherosclerosis(subAs)in patients with newly-diagnosed type 2 diabetes(T2DM).Methods In the prospective study,141 patients with newly-diagnosed T2DM without subAs were designed to experience the prospective targeted multifactorial intervention,including intensive control of blood glucose,blood pressure,blood lipids and body weight.The influences of multifactorial intervention and change of MS score on incidence of subAs after 6 years were analyzed.Results MS scores after 1 year intervention were significantly improved(P<0.01).The incidence rate of patients whose MS scores remained equal to or greater than 2 after 1 year intervention was significantly higher than those whose MS scores were 0 or 1 after 1 year intervention(P<0.05).The incidence rate of those whose MS scores remained 2 after 1 year intervention was 74.1%(20/27),while the incidence rate of those whose MS scores remained 3 after 1 year intervention was 100.0%(6/6).Multiple stepwise Logistic regression analysis showed that after adjustment of age and sex,MS score after 1 year intervention is independent variable of incidence of subAs after 6 years(OR=1.89,95%CI 1.19～3.01,P<0.01).Further analysis revealed that after adjustment of age and sex,central obesity after 1 year intervention was the most marked factor on subAS after 6 years among all the MS components except for hyperglycemia(OR=2.45,95%CI 1.19～5.07,P<0.05).Conclusion The early-stage metabolic syndrome intervention efficacy may predict long-term subAs outcome in patients with newly-diagnosed T2DM.Central obesity is the most important factor which deteriorates long-term subAs.