AimTo explore the glycoprotein Ⅱb/Ⅲa receptor antagonist, tirofiban, on the plasma inflammatory factors of rabbits in vivo, and find some theoretical basis for appropriately using the glycoprotein Ⅱb/Ⅲa receptor antagonists in atherosclerosis.MethodsNew Zealand rabbits were fed with hyper-cholesterol forage for 12 weeks to form atherosclerosis.The rabbits were divided to 4 groups (n=8), and had intravenous drip natural saline, 3.125 mg/L, 12.5 mg/L or 50 mg/L tirofiban in different group respectively. After the intravenous drip started for 0 h, 12 h, 24 h and 48 h, the platelet maximal aggregating rates ［PAG(M)］ were detected using turbidity method, the interleukin-6, interleukin-1β and tumor necrosis factor-α (TNF-α) level in the plasma were detected using enzyme linked immunosorbent assay (ELISA).Parameters differences among 4 groups were compared.ResultsAfter intravenous dripping started for 12 h, 24 h and 48 h, PAG(M) was reduced (PANOVA<0.05), P-selectin, interleukin-6, interleukin-1β and TNF-α were reduced (PANOVA<0.05) along with the tirofiban concentration increase.In control group and 3.125mg/L tirofiban group, PAG(M) had no difference after intravenous dripping started for 12 h, 24 h and 48 h (P>0.05). PAG(M), P-selectin, interleukin-6, interleukin-1β and TNF-α were reduced significantly (P<0.05) when ≥12.5 mg/L tirofiban was intravenous dripped.ConclusionThe PAG(M) and inflammatory factors were not affected when tirofiban was intravenous dripped in small dosage.When the tirofiban was intravenous dripped in medium or large dosage, the PAG(M) and inflammatory factors were inhibited significantly.