AimTo investigate the relationship between －413A/T single nucleotide polymorphism in heme oxygenase-1(HO-1) gene promoter and susceptibility of coronary artery disease.Methods200 patients who were diagnosed as having coronary artery disease by coronary angiography were selected in this study.120 subjects without evidence of coronary artery disease under coronary angiography with their sex and age similar to coronary artery disease patients were selected as controls.Sequencing was carried out on the ABI 3730 DNA analysis platforms to determine the genotypes of －413A/T.ResultsA single nucleotide polymorphism A(－413)T was found in the HO-1 gene promoter. Genotype T/T was protective against coronary artery disease in patients with dyslipimedia (adjusted OR=0.179, 95%CI=0.05～0.642).ConclusionA(－413)T single nucleotide polymorphism may be an important marker to evaluate susceptibility to coronary artery disease in patients with dyslipidemia.