Aim To investigate the association between the polymorphisms of angiotensinogen gene(AGT235),angiotensin converting enzyme gene(ACEI/D),atrial natriuretic peptide gene(ANP2238) and essential hypertension in a southern Chinese Han population.Methods Performed by gene chip technology,the genotypes of 81 essential hypertensive people and 120 control people were measured to analyze the polymorphisms of AGT235,ACEI/D and ANP2238.Results A significantly higher frequency of ACEI/D DD genotype was observed in hypertensive group(48.1% vs 4.2%,P<0.001) than in control group.In hypertensive group,the frequency of AGT235 TT genotype and ANP2238CC genotype was respectively 53.1% and 6.1%,while it was respectively 45.8% and 8.3% in control group.No significant differences were observed(P>0.05).Conclusion The polymorphism of ACEI/D gene is related to essential hypertension.