Aim To explore the effect of fenofibrate(Fen) and pioglitazone(Pio) on arteriae aorta remodeling in the fructose-induced metabolic syndromic(MS) Rats.Methods SD rats breeded with high fructose fed to raise MS rats,and Fen or Pio were used to intervent MS rats singly and jointly.The differences in arteriae aorta morphosis of MS rats were analyzed and compared among groups with different intervents.Results The arteriae aorta remodeling were amended in MS rats intervened by Fen and Pio.Relative to MS rats,rats intervened with Fen or Pio singly exhibited a more smoothing aortic tunica intima,less vascular medio-smooth muscle proliferation,and thinner vascular wall.Pio-intervention even displayed a more regular array of medio-smooth muscle cell and elastic fibers.Combination with fenofibrate and pioglitazone intervented MS rats,which built a more normal arteriae aorta in morphosis.Conclusions Intervention with fenofibrate or pioglitazone singly can restrain arteriae aorta pathologic remodeling in MS rats.The effectiveness of pioglitazone is more significant than that of fenofibrate.Synergistic effect of fenofibrate and pioglitazone can further improve and even reverse the vascular remodeling in MS rats by different mechanisms and acting targets.