Aim To study the effects of macrophage-derived lipoprotein lipase(LPL) on the lipid metabolism in inherited hypertriglyceridemia mice. Methods After lethal irradiation,8 female LPL-deficient(LPL-/-,LK) mice were divided into two groups and reconstituted by bone marrow transplantation(BMT)from male C57BL(LPL+/+,WT) and LK mice,respectively.Plasma levels of triglyceride,total cholesterol were surveyed,plasma lipoprotein profile was detected by fast protein liquid chromatography(FPLC),and LPL activities were assayed at week 4 post-BMT. Results It was demonstrated that plasma triglyceride(TG) and cholesterol(Chol) levels in BMT(WT→LPL-/-) mice were reduced by 83.2%(P<0.05,n=4) and 74.4%(P<0.05,n=4) compared with those in LPL-/-→LPL-/-mice,while similar reduction by 86.2% and 78.8% in TG and Chol before and after BMT were observed in WT→LPL-/-mice.Post-heparin plasma LPL activities were increased by 4.5-fold after BMT.There were no effects of BMT in LK→LK mice on TG,Chol and LPL activities. Conclusion Macrophage-derived LPL plays a significant role in the lipid metabolism,and improves lipoprotein disorder in inherited hypertriglyceridemia mice.