Aim To research the change of plasma soluble CD40 ligand (sCD40L) in the patients with coronary heart disease,and the influence of EXCEL stent on sCD40L. Methods 80 patients were divided into BMS group and EXCEL group according to different treatment from January 2006 to June 2008. 40 cases in each group were followed up by coronary artery angiography. The level of sCD40L was measured on 1,3 ,6 months after operation. Results The difference of the level of sCD40L was significant on 1,3 months after operation between the two groups (P<0.01),but no significant difference on 6 months (P>0.05). Conclusion EXCEL stent could reduce plasma sCD40L with proper endothelialization to decrease restenosis and delayed thrombosis.