Aim To observe the effect of atorvastatin on the expressions of angiotensin-converting enzyme 2(ACE2) within heart in two kidney and one-clip(2K1C) hypertensive rats.To discuss new possible mechanism of atorvastatin on improving myocard remodeling. Methods Fifty adult male Wistar rats were randomly divided into five groups(n=8): control group,2K1C hypertension group,valsartan group,atorvastatin 10 mg/(kg·d) group and atorvastatin 30 mg/(kg·d) group.SBP was measured before making 2K1C hypertension model,after drugs were given for 4 weeks and 8 weeks by tail-cuff method. After 8 weeks,entire heart,and left ventricle were weighed.The left ventricular weight index was calculated.The distribution and expression of ACE2 in heart were detected by immunohistochemistry and the expression of ACE2 mRNA was determined by RT-PCR.The myocardial angiotensinⅡlevel was measured by radioimmunoassay. Results The high dose atorvastatin and valsartan group could make SBP significantly decreased compared with the hypertension group(P<0.01).(2) Compared with the hypertension group,entire heart weight,left ventricular weight and left ventricular weight index were decreased in the control,high dose atorvastatin and valsartan group after all drugs were given for 8 weeks(P<0.05).(3)The level of angiotensinⅡin rat myocard tissue was decreased in high dose atorvastatin group compared with that of the hypertension group(P<0.01).(4)The expression of ACE2 protein was increased in the valsartanan,low and high dose atorvastatin group compared with that of the hypertension group.(5) ACE2 mRNA in heart was expressed in all rats.The levels of ACE2 mRNA expression increased differentially by valsartan,low and high dose atorvastatin treatment compared with that of the hypertensive group(P<0.05). Conclusion Atorvastatin can improve myocard remodeling along with SBP decreases.The myocard remodeling effect of atorvastatin may be ascribed to the increased ACE2 in heart,the decreased angiotensinⅡin myocard tissue.