Aim To investigate the influence of ralated factors to different antihypertensive effective rate of metoprolol with the same genotypes of CYP2D6 and β1-adrenergic receptor (β1-AR). Methods 63 cases of 1 or 2 grade essential hypertension patients with the *10*10 of CYP2D6*10 genotype and Arg/Arg of β1-AR Gly389Arg genotype were chosen and administrated with metoprolol 100 mg/d. Indexes, such as blood pressure and heart rate, were collected every two weeks during the follow-up visit. After 8 weeks, the relationships between the related factors, such as age, baseline blood pressure, body mass index (BMI), hyperlipidemia and smoking, and antihypertensive effective rate of metoprolol were analysed. Results According to antihypertensive efficacy, 40 patients were effective to metoprolol, while 23 were ineffective. The effective rate was 63.5%. Monofactorial analysis indicated that patients with higher baseline systolic blood pressure and normal BMI had greater effective rate than the others (P<0.05). Furthermore, multifactoring regression analysis also claimed that baseline systolic blood pressure showed the significant effect to metoprolol. Conclusion Baseline blood pressure and BMI are related to the different antihypertensive effective rate of metoprolol.