冠心病患者不同类型血清氧化型低密度脂蛋白和高敏C反应蛋白水平的差异
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The Difference of Serum Oxidized Low Density Lipoprotein and High Sensitive C-Reactive Protein Among Different Types of Patients with Coronary Heart Disease
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    摘要:

    目的比较血清氧化型低密度脂蛋白、高敏C反应蛋白水平在不同类型冠心病中的差异。方法检测了82例冠心病患者(急性冠状动脉综合征42例、稳定型心绞痛20例和陈旧性心肌梗死20例)和22例正常对照者血清氧化型低密度脂蛋白、高敏C反应蛋白、高密度脂蛋白胆固醇、总胆固醇和高密度脂蛋白胆固醇水平,并比较各指标水平在不同类型冠心病中的差异。结果血清氧化型低密度脂蛋白水平在冠心病组明显高于对照组(62.5±24.8μg/L比42.3±17.9μg/L,P<0.05),在急性冠状动脉综合征组明显高于稳定型心绞痛组和陈旧性心肌梗死组(68.9±23.4μg/L比41.5±21.3μg/L和50.5±21.6μg/L,P<0.05);血清高敏C反应蛋白水平在冠心病组明显高于对照组(15.58±4.32mg/L比6.94±1.93mg/L,P<0.05),在急性冠状动脉综合征组明显高于稳定型心绞痛组和陈旧性心肌梗死组(19.31±1.43mg/L比10.29±1.01mg/L和9.56±1.72mg/L,P<0.05);血清低密度脂蛋白胆固醇水平在冠心病组明显高于对照组(3.46±1.11mmol/L比2.87±+0.82mmol/L,P<0.05),但在急性冠状动脉综合征组与稳定型心绞痛组和陈旧性心肌梗死组差异无显著性(3.64±0.85mmol/L比3.06±1.23mmol/L和3.40±1.35mmol/L);血清总胆固醇/高密度脂蛋白胆固醇比值在冠心病组明显高于对照组(3.46±1.11比2.87±0.82,P<0.05),在不同类型冠心病中亦有差异(P<0.05)。结论血清氧化型低密度脂蛋白和高敏C反应蛋白水平及总胆固醇/高密度脂蛋白胆固醇比值在冠心病不同类型中有差异,可能为诊断冠心病的指标。

    Abstract:

    Aim To compare the difference of levels of serum oxidized low density lipoprotein(ox-LDL)and high sensitive C-reactive protein(hs-CRP)among different types of coronary heart disease.Methods Levels of serum ox-LDL and hs-CRP and low density lipoprotein cholesterol(LDLC),total cholesterol(TC)and high density lipoprotein cholesterol(HDLC)were measured among 82 patients with coronary heart disease including 42 acute coronary syndrome(ACS),20 stable angina pectoris(SAP)and 20 old myocardial infarction(OMI)and 22 normal healthy control subjects,then the differencs of levels of all four markers were compared among different types of coronary heart disease.Results Serum ox-LDL levels in the coronary heart disease group(62.5±24.8 μg/L)were significantly higher than that in normal healthy control group(42.3±17.9 μg/L,P<0.05),and serum ox-LDL levels in ACS group(68.9±23.4 μg/L)higher than that in SAP group(41.5±21.3 μg/L)and serum ox-LDL levels in OMI group(50.5±21.6 μg/L,P<0.05);serum hs-CRP levels in coronary heart disease group(15.58±4.32 mg/L)were significantly higher than that in normal healthy control group(6.94±1.93 mg/L,P<0.05),and serum hs-CRP levels in ACS group(19.31±1.43 mg/L)higher than that in SAP group(10.29±1.01 mg/L)and serum hs-CRP levels in OMI group(9.56±1.72 mg/L,P<0.05);serum LDLC levels in coronary heart disease group(3.46±1.11 mmol/L)were significantly higher than that in normal healthy control group(2.87±0.82 mmol/L,P<0.05),and serum LDLC levels in ACS group(3.64±0.85 mmol/L)higher than that in SAP group(3.06±1.23 mmol/L)and serum LDLC levels in OMI group(3.40±1.35 mmol/L,P>0.05).Serum TC/HDLC in the coronary heart disease group(3.46±1.11)were significantly higher than that in normal healthy control group(2.87±0.82).Serum TC/HDLC in different types of patients with coronary heart disease were different(P<0.05).Conclusions The levels of serum ox-LDL and hs-CRP and TC/HDLC have differences among different types of coronary heart disease,and these may be targets of coronary heart disease.

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赵庆霞,李海涛,刁增利.冠心病患者不同类型血清氧化型低密度脂蛋白和高敏C反应蛋白水平的差异[J].中国动脉硬化杂志,2008,16(7):559~561.

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  • 收稿日期:2008-04-08
  • 最后修改日期:2008-07-01
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