Aim To investigate the effect of angiotensin system blockers on the levels of serum angiotensin Ⅱ(Ang Ⅱ),interleukin-1(IL-1),C-reaction protein(CRP) and lipid metabolism in patient with chronic glomerular disease. Methods 89 cases of chronic glomerular disease were randomly divided into 3 groups: benazepril group(n=30),valsartan group(n=30) and combination of benazepril and valsartan group(n=29).Serum Ang Ⅱ,IL-1,CRP,quantity of 24 hour urinary protein and lipid were measured before and after 8～12 weeks therapy. Results Serum total cholesterol were effectively decreased in 3 groups after therapy.Combination of benazepril and valsartan therapy reduced triglyceride effectively.Benazepril group and combination of benazepril and valsartan group have more influence on the low density lipoprotein(LDL),apolipoprotein B than valsartan group(P<0.01).Meanwhile the levels of serum Ang Ⅱwas effectively decreased in benazepril group and combination of benazepril and valsartan group(P<0.05),in contrast to valsartan group,the level of serum Ang Ⅱ was increased(P<0.05).The levels of serum IL-1 and CRP were significantly reduced after therapy(P<0.05).Therapeutic alliance group decreased proteinuria more effectively than that of benazepril alone or valsartan alone(P<0.05). Conclusions The combination of benazepril and valsartan may reduce the level of serum Ang Ⅱ,IL-1 and CRP,decrease urine protein excretion and ameliorate lipid metabolism in patients with chronic glomerular disease.