Aim To investigate the correlation between glycosylated hemoglobin A1c(GHbA1c) and Ⅶ factor activity in type 2 diabetic patients with different types of coronary heart disease(CHD).Methods Concentrations of GHbA1c and plasma activities of Ⅶ were measured in 73 patients with difference types of coronary heart disease and 40 T2 diabetic patients.Results In the patients of actual myocardial infarction and unstable angina pectoris Ⅶ activity was significantly higher than those of diabetic patients(p<0.05).In the old myocardial infarction and stable angina pectoris Ⅶ activity was higher than those of normal controls(p<0.01).There was a positive correlation between the concentration of GHbA1c and activity of Ⅶ in all the patients and controls.Conclusion Concentration of blood glucose positively correlated with Ⅶ factor.Serum blood glucose may play an important role in the pathogenesis of T2 diabetes mellitus by inducing coagulative and fibrinolytic dysfunction.