Aim To investigate the dynamic changes of adrenomedullin specific receptors components,calcitonin receptor-like receptor(CRLR),receptor activity modifying proteins 2(RAMP2) and RAMP3 mRNA expression in the stress-induced-hypertensive rats.Methods Distribute 48 rats to control group with 18 of them and stress group with 30 of the total randomly.Noise with electric foot shock upon the stress group.Execute all the rats and separate their hypothalamus to isolate the total RNA individually at stress 1,5,10 and 15 d and poststress 5 and 10 d.Determine the changes of the adrenomedullin,CRLR and RAMP mRNA expression of by reverse transcription-polymerase chain reaction(RT-PCR).Results Compared with control group at the same time point,CRLR mRNA expression in hypothalamus upregulated within foot-shock and sound stress 10 d(1.236±0.040 vs 0.941±0.041,p<0.01),then downregulated to a lower level at stress 15 d(0.860±0.041 vs 0.938±0.042,p<0.05);RAMP2 mRNA expression in hypothalamus upregulated to the highest lever at stress 5 d(1.160±0.045 vs 0.897±0.036,p<0.01),then downregulated to a lower lever at stress 15 d and poststress 5 d(0.670±0.021 vs 0.897±0.041,0.719±0.039 vs 0.910±0.032,p<0.01);However RAMP3 mRNA expression upregulated to the highest lever at stress 1 d(1.197±0.053 vs 0.870±0.039,p<0.01),then downregulated to a lower lever at 10,15 d and poststress 5 d(p<0.05 or p<0.01).Even at poststress 10 d,the level of RAMP3 expression still lower than control group at the same time point,but no statistic significance.Conclusion According to the results described above,at the gene level,the expression of ADM specific receptor components CRLR,RAMP2 and RAMP3 mRNA had changed to some degree in the process of chronic stress-induced-hypertension,indicating that ADM specific receptors maybe involve in the stress-induced-hypertension.