Aim To investigate the possible interaction of cholesteryl ester transfer protein(CETP) level with the lipid transport between the lipoproteins.MethodsTriglyceride levels in lipoproteins were determined by agarosis gel electrophoresis with enzyme colouration.plasma CETP and oxidized low-density lipoprotein(ox-LDL) levels were both determined by enzyme-linked immunosorbent assay(ELISA).The correlations between CETP and lipid levels were also studied.ResultsCETP levels in hypertriglyceridaemia,hypercholesterolaemia,complex hyperlipidaemia and control subjects were 1.89±1.32,2.37±1.30,2.33±1.73 and 1.58±1.00 mg/L,respectively,which didn't change significantly in hypertriglyceridaemia group(p<0.05),while increased in hypertriglyceridaemia(p<0.01) and hypertriglyceridaemia(p<0.05).Compared with the control group,the ratios of cholesterol/triglyceride in high density lipoprotein(HDL) decreased in hyperlipidaemia subjects.The ratios of cholesterol/triglyceride in LDL increased both in hypertriglyceridaemia and complex hyperlipidaemia groups,while showed no difference in hypercholesterolaemia group.The two ratios in hypertriglyceridaemic subjects both exhibited the most significant change,while hypercholesterolaemic subjects the least.CETP level had positive correlation with the ratios above.Morever,oxidized LDL level was also found to have positive correlation with LDL-TG/LDLC ratio.ConclusionsThe high CETP level in hyperlipidaemia subjects promoted the transport of lipids between lipoproteins,which changed the composition of HDL and LDL and was involved in the development of atherosclerosis.