Aim Detected the expression of stromal cell-derived factor-1(SDF-1) in atherosclerotic lesions induced by low shear stress to research the roles of SDF-1 in atherosclerosis formation and development.MethodsWe set up a local stenosis in left carotid artery,then stimulated the local hemodynamics at the down-stream of stenosis with numerical simulation;HE staining was taken to identify the pathology of common carotid artery;Immunochistochemistry staining was used to detect the expression in atherosclerotic lesions.ResultsThere was a low shear stress region(0～0.3 Pa) at distal of ring where there was obvious atherosclerosis lesions formated.The intimal of control group (8±3μm) is obviously lowed than the treated group(4 weeks 38.5±12.7 μm,8 weeks 95.3±19.6 μm).Immunochistochemistry showed that SDF-1 highly expressed in atherosclerotic plaque without expression in control.ConclusionSDF-1 may play important roles in atherosclerosis formation and development induced by low shear stress.