Aim To investigate the effects of high dose atorvastatin on the antioxidation activity in patients with acute coronary syndrone(ACS). Methods 168 patients with ACS were divided randomly into two groups patients.Patients in a group were treated with high dose atorvastatin(40 mg/d),and in another group with low dose atorvastatin(10 mg/d).Superoxide dismutase(SOD),GSHPx,malondialdehyde(MDA) measurment were taken before the treatment,on the 1 week and 2 week.50 healthy volunteers were assigned to the normal control group. Results SOD,GSHPx activity were lower significantly in patients with ACS compared with those of the nomal control subjects(83.24±21.45 ku/L and 80.53±19.67 ku/L vs 104.53±21.87 ku/L,1 327.7±426.5 ku/L and 1 341.2±396.8 ku/L vs 1 681.2±385.8 ku/L,p<0.01),and MDA was higher significantly in patients with ACS compared with those of the nomal control subjects(6.23±2.13 mmol/L and 6.02±1.89 mmol/L vs 3.52±2.09 mmol/L,p<0.01).After 1 week atorvastatin treatment,the SOD,GSHPx,MDA activity of the patients with high dose atorvastatin were improved significantly(91.56±23.64 ku/L vs 80.53±19.67 ku/L,1 483.3±402.3 ku/L vs 1 327.7±426.5 ku/L,p<0.05,4.57±2.37 mmol/L vs 6.23±2.13 mmol/L,p<0.01),which were much better in group high dose atorvastatin than those in group low dose atorvastatin(p<0.05). Conclusions The short-term treatment with high-dose atorvastatin could enhance the ability against superoxide injury in patients with ACS.