Aim To study the relationship between the angiotensiongen gene M235T polymorphism and coronary vessel disease in Chinese people from Shanxi and its vicinity. Methods Polymerase chain reaction combined with restriction enzyme digestion was used to study 152 patients who were accepted coronary angiography.Genetype and allele frequency of the patients was compared according to the number of coronary vessel disease and mean coronary heart disease(CHD) scores. Results The TT genetype and T allele frequency are different in the patients for the viration of the number of coronary vessel disease and mean CHD scores(χ~2=29.537,28.560,31.970,31.771 respectively,p<0.01). Positive correlation is existed in T allele frequency and the number of disease or scores(r=0.396,0.355 respectively,p<0.01). Conclusions There is an association between gene variants of the angiotensinogen and the number of coronary vessel disease and mean CHD scores.The number of coronary vessel disease and mean CHD scores will be higher gradually with the increase of T allele frequency.