Aim To observe the lipoprotein regulation effect and the reuction of inflamatory infactors of 40 mg/d and 10 mg/d atorvastatin on patients with acute coronary syndromes(ACS) after percutaneous coronary intervention(PCI). Methods 92 patients with ACS after PCI were randomly devided into two groups: control group(atorvastatin 10 mg/d) and trial group(atorvastatin 40 mg/d).Serum concentration of ultrasensitive C-reactive protein(Us-CRP)and matrix metalloproteinases-9(MMP-9)were detected by enzyme linked immunosorbent assay(ELISA) to analyse the difference between two groups. Results Serum total cholesterol(TC) in trial group was lower than that in control group at 12th week(p<0.05),and serum TC and low density lipoprotein cholesterol(LDLC) in trial group were lower than those in control group at 24th week(p<0.01).Serum concentration of MMP-9 in trial group was lower than that in control group at 12th week(p<0.01).Moreover,serum concentration of Us-CRP in trial group was also lower than that in control group at 24 th week(p<0.05). The bivariate correlation analysis showed there were linear dependence association between the decline of serum concentration of Us-CRP and MMP-9 vs TC and LDLC.There was no significant difference of the patients' recurrent coronary artery events between the two groups. Conclusion ①Atorvastatin 40 mg/d was safe on Chinese patients.②Atorvastatin 40 mg/d increased the rate of reaching the lipoprotein regulation goal.③There were linear dependence association between the decline of serum concentration of Us-CRP,MMP-9 and the level of TC,LDLC.