Aim To explore effects of lycopene(LP) on lipidemia,blood coagulation and fibrinolysis in experimental hyperlipidemia rats. Methods Experimental hypertriglyceridemia rats were intragastrically administrated with LP [20 mg/(kg·d)] or 0.5% carboxymethyl cellulose sodium [CMC-Na,10 mL/(kg·d)] for 30 days.The levels of plasma triglyceride(TG),total cholesterol(TC),high density lipoprotein cholesterol(HDLC),prothrombin time(PT),activated partial thrombplastin time(APTT),plasminogen activator inhibitor1(PAI-1) activity and tissue plasminogen activator(t-PA) activity were measured according to the direction of the kits. Results Feeding high carbohydrate and fat diet(HCFD)to rats,plasma TG was 1.95 times of the normal dietary rats.The plasma HDLC of HCFD group was 26% lower than that of the control group.Feeding HCFD and LP to rats,plasma TG was 24% lower and plasma HDLC was 32% higher than that of the HCFD group.The PT and APTT of HCFD group were significantly shorter than that of the control group(p<0.01).The PAI-1 in HCFD group was higher than that of the control group(p<0.01).The PAI-1 and t-PA of LP and HCFD group were higher than those of the control group(p<0.01). The PT and APTT of the LP and HCFD group were significantly longer than those of the HCFD group(p<0.01).The PAI-1 in LP and HCFD group was lower(p<0.05) and the t-PA in LP and HCFD group was higher than that in the HCFD group(p<0.01). Conclusion Lycopene could decrease level of plasma lipids and the activity of blood clotting system and enhance the activity of fibrinolysis system.