Aim To explore the feature of MRI and clinical manifestations of unusual widening of Virchow-Robin space in the brain.Methods 21 patients' MRI and clinical data were analyzed respectively.Results Headache and epilepsy episodes were common clinical symptom.Moreover most patients were accompanied by hypertension and cerebrovascular disease.Unusual widening of Virchow-Robin spaces on MRI were divided into three types according to anatomic location,typeⅠat ganglia,typeⅡat semioval centrum,type Ⅲ at other location.Unusual dilated Virchow-Robin spaces were classified into four sorts by morphology characteristics, typeⅠmono-vesicle,typeⅡfocal cluster,type Ⅲ dense vesicles mostly located unilaterally,type Ⅳspider net-like.Conclusions Unusual widening of Virchow-Robin Spaces in the brain had some characteristic manifestations on MRI.However, its clinical manifestations were lack of characteristic and the relation of headache and epilepsy with unusual dilated Virchow-Robin space still needs further investigation.