Aim To investigate the relation of Helicobacter pylori (HP) infection and coronary heart disease (CHD). Methods HPIgG was measured in total 101 cases of CHD and 53 healthy subjects. Interleukin-6 (ELISA) and endothelin-1 (RIA) and total cholesterol (TC), triglyceride (TG), apolipoprotein A (ApoA), apolipoprotein B(ApoB), high density lipoprotein (HDL), low density lipoprotein(LDL), were measured in 101 cases of CHD. Results The rate of seropositive for HPIgG in CHD patients is significantly higher than that of controls(45.5% vs 28.3%,p<0.05), the level of plasma endothelin-1 in these of HPIgG seropositivity is higher than that of HP seronegativity (p<0.05) and there was no correlation between chronic HP infection and essential hypertension, diabetes mellitus, tobacco use, age, gender, alcohol consumption and family history. Conclusion Chronic HP infection may be associated with CHD. Chronic HP infection may act through changing endothelin function, which contribut to the pathogenesis of CHD.