Aim To observe the effect of anti-oxidizer's improving vascular endothelial function on the early damage of the kidney in hypertension patients. Methods 120 subjects were randomly divided into pressure-lowering control group and anti-oxidizing treating group. Ultralente-nifedipine and probucol in addition to ultralente-nifedipine together were respectively given to the two groups for 12 weeks, and the changes of blood lipoprotein, endothelins(ET), β 2-MG in blood and urine and Alb in urine before treatment with those after treatment. Results First, there were the damage of endothelial function and the early damage of the kidney. Second, there was obvious decrease in ET-1, low-density cholesterol, β 2-MG in blood and urine and Alb in urine after treatment, and the difference was significant (p<0.05); while the above indexes decreased more remarkably in the anti-oxidizing treating group (p<0.01). Conclusions Anti-oxidizing treating can improve vascular endothelial function and diverse the early damage of the kidney in the hypertension patients better than only pressure-lowering treatment. It was pointed out that endothelins damage possibly had some association with the damage of the kidney in the hypertension patients.