Aim To observe the effect of Recipe of Removing Both Phlegm and Blood stasis on aorta and cardiac muscle of rabbits as well as ultrastructure of endothelial cells. Methods The rabbits were fed with high fat diet in order to reproduce hyperlipemia models; The endothelial cells were cultured in high fat serum to observe the effect of hyperlipemia on it. They were treated by two kinds of recipes. In this experiment the ultrastructure of endothelial cells (EC), aorta and cardiac muscle was observed through electron microscope. Results Recipe of Removing Both Phlegm and Blood stasis group: Smooth tunica intima of aorta, little formation sclerosis plaque of aorta, dense and regular arrangement of endothelial cells, recovered cell appearance, regular arrangement of cardiac muscle, slight adipose tissue infiltration in cardiac muscle, no myofilament solution and decrease of expansion of sarcoplasmic reticulum. The results showed that recipe prevented EC, aorta and cardiac muscle from injury. Conclusion Recipe of Removing Both Phlegm and Blood stasis can be used against myocardial ischemia, prevent vasospasm, platelet aggregation and arteriosclerosis.