Aim To observe the antiatherogenetic effect of batata glycoprotein (BG) and its mechanisms. Methods Fourty adult male New-Zealand rabbits were randomly divided into normal control group, hyper-cholesterol group, low dose BG and high dose BG group. Each group was fed respectively with common forage, high cholesterol forage, high cholesterol forage andding BG (0.06g/kg.d ) and high cholesterol forage andding BG (0.1g/kg.d ). At week 0 and 12, the levels of total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDLC) and high density lipoprotein cholesterol (HDLC) in the serum were determined. The levels of serum superoxide dismutase (SOD) activity and malonyldialdehyde (MDA)were measured. At the end of the twelfth week, all rabbits were killed to observe aorta pathological changes. Results At the end of the twelfth week, the levels of serum TC, TG, LDLC and MDA were lightly decreased or significantly decreased in low dose group and high dose group compared with those in hypercholesterol group (hypercholesterol group, low dose group and high dose group: TC was respectively 20.26±0.13, 15.27±0.83, 11.28±1.62. TG was respectively 1.85±0.35, 1.71±0.28, 1.51±0.11. LDLC was respectively 18.99±2.65, 14.27±3.04, 12.13±3.56. MDA was respectively 4.53±0.34, 4.13±0.18, 3.83±0.26 p<0.01), while the levels of serum HDLC and SOD activity were increased or significantly increased in low dose group and high dose group compared with those in hypercholesterol group (hypercholesterol group, low dose group and high dose group: HDLC was respectively 0.75±0.10,0.81±0.06,0.94±0.08. SOD was respectively 156±16, 186±21, 231±6, p<0.05 or p<0.01). Plaque area of low dose group and high dose group was smaller than that of hypercholesterol group (p<0.05 or p<0.01). Conclusions Batata glycoprotein can inhibit atherogenesis, and the effect correlates with the amount of adding batata glycoprotein.