Aim To explore the correlation between incidence of coronary heart disease (CHD) and the changes of markers of coagulation, fibrinolysis in patients with CHD. This may help to diagnosis, anticoagulation, thrombolysis and prognosis for patients with CHD. Methods Plasma platelet granule membrane protein 140 (GMP-140), von Willebrand factor (vWF), D-dimer (D-D) were detected by enzyme linked immunosorbent assay (ELISA) in 100 patients with CHD, and compared with 42 healthy subjects. Results Plasma GMP-140, vWF, D-D were significantly elevated in patients with CHD and differed significantly compared with control group (p<0.01). The changes of molecular markers in patients with acute myocardial infarction (AMI) were elevated significantly than those with old myocardial infarction (OMI), unstable angina (UA) and stable angina (SA) (p<0.01). The levels of plasma GMP-140 in patients with UA were elevated more significantly than those with SA (p<0.05). There were obvious correlations between the molecular markers in patients with CHD(r=0.857～0.301, p<0.01). Conclusions An obvious hypercoagulable state existed in patients with CHD. There were correlations between the changes of molecular markers of hypercoagulable state and patients, condition.