Aim To study the inhibitory action of Oyster Extract (OE) on atherosderosis and it's mechanism. Methods The model of experimental atherosclerosis in quail was established by hyper lipoidal feed. The content of serum lipid and apolipoprotein was detected with enzyme method and immunization photoextinction. The atherosclerotic plaque lesion of aortic and coronary artery were observed by eyes and through light microscope.The serum superoxide dismutase (SOD) and malondiadehyde (MDA) in quail were observed with microcontent fast detecting method. Results Oral administration OE 10 g/(kg·d) for an 8 weeks period significantly reduced the degree of atherosclerotic lesion in aortic and coronary arterious endothelium in OE group. The serum total cholesterol (TC), triglycerides (TG), low density lipoprotein cholesterol (LDLC) and apolipoprotein B (Apo B) are 17.47±0.78, 1.16±0.35, 10.94±3.17 mmol/L and 2.47±0.78 g/L respectively in OE group at 4 weeks,and were less than model group (p<0.05,p<0.01). At 8 weeks OE marked reduced the TC, TG, LDLC, and ApoB in serum and TC, TG in cardial muscle and aorta (p<0.05,p<0.01). At the same time and serum SOD in serum was 415.55±72.48 k u/L in OE group.It was higher than model group (p<0.05). Conclusions OE has an inhibitory effect on the development of experimental atherosclerosis lesions in quails, the mechanism may be related to regulation of lipid metabilism and antioxidation action.