Aim To investigate the changes of plasma homocyst eine and lipid before and after therapy. Methods Simavatatin tablet s and/or Lipanthyl tablets were used to treat hyperlipidemic patients. Folate and Vitamin B 12 were used to tr eat hyperhomocysteinemia. Plasma homocysteine and lipid were detected before an d after treatment. Results After treatment of hyperl ipidemic patients, the decrease of lipid was significant but the decrease of hom ocysteine was not. After treatment of hyperhomocysteinemia, the decrea se of homocysteine was significant whilc the decrease of lipid was not. Conclusions With the treatment of hyperlipimia using Simava tatin tablets and Lipanthyl tablets, the plasma lipid decreased significant ly, but the plasma homocysteine decreased nonsignificantly. The plasma hom ocysteine decreased strongly by using Folate and Vitamin B 12 , but the chan ges of lipid were not significant.