Aim To explore the levels of blood glucose and insulin and the characteristics of tissue structure changes of livers, kidneys and pancreas in New Zealand white rabbits as diabetogenic diet (high fat and high sucrose) induced atherosclerosis in them. Methods Male New Zealand white rabbits were divided into two groups: normal fodder group (n=15) and high-sugar and high-fat fodder group (n=15, with 10% lard, 37% white cane sugar and 53% nomal fodder), and observed for 6 months. Once a month after a overnight fasting the blood of the rabbits are tested for the levels of blood glucose, insulin. At the end of 6 months all the rabbits were killed to get the livers, kidneys and pancreas, which were fixed with 10% formalin sectioned with regular paraflin wrapping. stained with H.E and PAS to livers sections, and then observed with microscopes. Results One month later the rabbits in the experimental group developed high blood glucose, rising with the experimental time course, while those in the contrast group didn't develop obvious rise in blood glucose. The differece between the two groups was significant (P<0.05). Five months later the liver cells in the rabbits of the experimental group developed clear steatosis and swelling with liver glucogen disappearing in the cell plasma. In the kidney the glomeruli became larger, the cell number increased, the walls of capillary vessel became thicker and the epicyte in the urinitubube became larger. The tissue structure in the pancreas develop obvious pathological changes. The pancreas islets are atrophied, there is a decrease of cell's amount in pancreas islets and there are a few lymphocyte infiltration around pancreas islets. Conclusion High-sugar and high-fat fodder can induce sustained and typical diabetes and atherosclerosis in New Zealand White rabbits within a short period of time.