Aim To evaluate the effects of postprandial hypertriglyceride on CHD in Chinese. Methods Fat tolerance test (fat: 53.4 g/m 2 body surface area)was performed in 61 subjects who were divided into two groups: CHD(n=30)and control(n=30). Concentration of triglyceride(TG) and high density lipoprotein cholesterol(HDLC) were determined before and 2,4,6,8 and 10 h after a standardized fat test meal. Both the peak concentration of postprandial TG (6.15±3.00 mmol/L) and the Area Under Curve [AUC, 25.96±14.33 mmol/(h·L)] of postprandial triglyceride concentration were higher in CHD than those [4.59±2.09 mmol/L and 14.69±6.58 mmol/(h·L),P<0.005] in control. The AUC is an independent risk factor of CHD by multivariate logistic-regression analysis. There is a positive correlation between AUC and the concentration of 6 and 8 h postprandial triglyceride(TG 6 or TG 8). Conclusions Our study indicated that there be abnormal postprandial hypertriglyceridemia in CHD. The abnormal postprandial hypertriglceridemia is an independent risk factor of CHD. The concentration of TG 6 or TG 8 may replaced AUC and simplify the fat load test.