Aim To observe the regulatory effect of cytokins on the expression of CD44, CD11b and Vn as well as the regulation change of cytokines to above antigen during coronary heart disease (CHD).Methods The distribution of CD44, CD11b and Vnon the mononuclear ce11s was displayed by means of immunohistochemistry, and followed by quantitative process with Quantimet 52O+image analysis system,Finaly, the data were Processed by factorial analysis of statistics.Results The positive area of CD44, CD11b and Vn shows pink or dark pink color, and display a ring,semilunar, cap, spot-flat or granular shape. The dis-tribution of the three antigens the mononuclear cell surfaces is different. Quantitative analysis indicates that the Sum value increased obviously as a result from the effect of cytokines (P<1. 001) Which showed more significant in patients with coronary heart disease than in control (P<0.001).Conclusion Interleukin-1, tumor necrosis factor and interleukin-6 may up-regulate the expression of the adhesive related proteins (ARPs) and the effect of in-terferon-alpha is less intensive in CHD. Which indi-cate that the sensitivity of CHD patient's ARPs expres-sion to regulatory effect of cytokines is much higher than that of normal people.The present study shows that the cytokines can affect the adhesion of mononu-clear cells to endothelium via the regulation of ARPs expression and then interfere with atherogenesis.