Aim To investigate the relationship between heavier proteinuria or hypoalbuminemis and serum lipid abnormalities in primary nephrotic syndrome.Methods Serum albumin, total cholesterol (TC),low density lipoprotein cholesterol (LDLC) and 24-hour urinary protein content were assayed in nephrotic syndrome patients (n=20) and healthy controls (n=20).Results Hyperlipidemia is a consistent feature of the nephrotic syndrome patients. 24-hour urinary protein content was positive correlated with the level of serum TC (r=0. 43, p<0.05), but no statistically significance was observed between proteinuria and serum LDLC (r =0. 37, P >0.05). The level of serum albumin was inversely significantly correlated with both the level of serum TC and LDLC (r=-0.69, p<0. 01, r=-0. 51, p<0. 01, respectively).Conclusion There were correlated relationship between proteinuria or hypoalbuminemia and serum lipid abnormalities in nephrotic syndrome.