To investigate the relationship between serum lipoprotein (a) [LP (a)], plasma fibrinogen (Fg) levels and coronary stenosis documented by angiography in patients with coronary heart disease (CHD). One hundred and thirty-seven cases undergone coronary angiography whose serum LP (a) and plasma fibrinogen levels were determined. Results show that the serum Lp(a) mean levels were higher in 61 cases of CHD with multi-vessels disease (VD) than 31 control with none vessel disease. Plasma Fg levels raised significantly in CHD cases of single and multiple VD groups than None VD group. There was a mild relation between LP (a) and Fg level in multi-VD group (r = 0. 37, p<0. 05, n = 53). This study suggests that LP (a) and Fg blood levels all increase significantly in CHD cases, and there is certain relation between them.