Aim To explore the correlation between thechanges of leukocyte deformability (LD), leukocyteadhesion function (LAF), expression of cell adhesionmolecule (CAM) and coronary heart disease (CHD).Methods Leukocyte filteration index (LFI), leuko-cyte adhesion rate (LAR), leukocyte CD18 expressionand serum soluble intercellular adhesion molecu1e-1(sICAM-1 ) were measured in 118 patients and 68 con-trols.Results LFI, LAR, leukocyte CD18 expression andsICAM-1 concentration were significantly higher in pa-tients than those in controls (p<0. 001 ),the increaseof all indicators were more obvious in acute myocardialinfarction(AMI) patients than those in unstable angina(UA) and old myocardial infarction (OMI) patients (p<0. 001). In CHD patients, the LAR and LFI werepositively correlaed to leukocyte CD18 expression andsICAM-1 concentration(p<0.001 ), the LFI was posi-tively correlated to the LAR(p<0. 001 ).Conclusions The decrease of LD and the increase ofLAF, leukocyte CD18 expression andsICAM-1 concentration might participate in the oecu-rance of CHD, and were closely related to the CHD pa-tients conditions.