Aim To study the changes of serum lipid,Apolipoprotein and fibrinogen in patients of coronaryheart disease with various extents coronary stenosis.Methods According to the extents of angiographiccoronary maximal stenosis, 29 patients with coronaryheart disease (CHD) were classified (I ) obviousstenosis group (OSG, narrowing in luminal diameter>50% ), (Ⅱ ) mild stenosis) group MS. 16 non-CHDpatients proved by angiography served as controls(CG).Results There were no signifiant difference fortotal cholesterol (TC ) among the three groups.Triglyceride (TG), apolipoprotein (apoA I, apoB),high density lipoprotein cholesterol (HDLC), TC/HDLC, TG/HDLC, fibrinogen (Fg), apoA I / apoBin CHD patients were significantly abnormal as com-pared with CG (p<0.05 or p<0. 01, respectively). While TG, HDLC, apoA I, TC/HDLC, TG/HDLCand Fg in OSG changed significantly as compared withMSG.Conclusion TG, HDLC, apo AI, TC/HDLC,TG/HDLC and Fg related to the extents of coronarystenosis and may be of predictable values in coronarystenosis.