Aim observing the anti-atherosclerotic effect of API0134 in vivo.Methods An atheroscletotic rabbit model fed by high cholesterol supplemented with bovine serum albu-min injection was established.Results In model group , the percentage of plaque covering aortic intima (PA ) was 51. 2 % ±20. 0%, the incidence of atherosclernois of small arteries (LA ) and the degree of stenosis of coronarye arteries (DS ) were 62. 4% ± 17. 4 % and 57.6% ±17.4% respectively.In AP10134 treated group, compared with model group. the PA was 7. 1% ± 4. 5 %, LA was 12. 5% ± 4. 8%, DS was 10. 6% ±3.4%. While in nifedipine treated group, the image analvsis gave a significantly bigher values than APIC134 treated group, but lower then those of model group.Conclusion API0134 exeits strong anti-atheroscle- rotic effect in experimental rabbit. Althouth nifedip-ine has the similar effeet but with a slightly weaker ac-tion.