Comparative studies of oxidative and glycosylated modification of low density lipoproteins (LDL) were made by biochemical, histochemical and morphometric analysis, in the meantime the effects of prostaglandin E(PGE) on the modified LDL were observed. The results showed that compared with the control's the antioxidizing enzyme activities in oxidized low density lipoprotein(OLDL) group decreased but lipid peroxide(LPO)content increased markedly, while PGE drugs elevated enzyme activities and inhibited LPO production. The results of morphometric studies confirmed that prostaglandin E₂(PGE₂) obviously inhibited foam cells formation. The mechanism of glycosylation was complicated. It was characterized only mildly decreased enzyme activities but markedly increasing of LPO content, suggesting that at the beginning it might be due to non-enzymatic glycosylation and then complicated with the so called glycosyldation of LDL, therefore heavily enhanced tissue injuries and diabetic atherosclerosis, This experiments showed that PGE, especially PGE₂ also possessed the protective effects to LDL glycosylation.