Effects of Oenothera biennis L complex prescription on plasma lipids and experimental athrosclerosis of rabbits were observed.In the proventive group with supplement of Oenothera biennis L complex prescription(1 g. k-1 per day)for 16 weeks, the levels of serum total chotesterol and low density lipoprotein significantly reduced(P <0. 01 and p< 0. 05, respectively),the level of serum high density lipoprotein cholesterol increased (p<0. 01), the proliferation of smooth muscle cells and the development of aortic atherosclerotic plague were inhibited.