Resistance to insulin-stimulated glucose uptake is present in the majority of patients with impaired glucose tolerance or non-insulin dependents diabetes millitus (NIDDM)and in obese. Coronary heart disease(CHD) is prevalent in both obesies and diabetic condition with insulin resistance.To test whether CHD is associated with insulin resistance independently of obesisty and diabetes,we measured serum insulin levels during oralglucose tolerance test(OGTT) in 32 patients with CHD,who have normal body weight, normal blood pressure, and normal OGTT,and 23 normal subjects. Plasma triglyceride(TG)and total cholesterol(TC) were determined in fasting condition and after glucose load.We found that the insulin levels of CHD is much higher than those of controls after glucose load, meanwheal TG and TC levels are higher than those of controls. The results showed that CHD exists insulin resistance state or hyperinsulinemia; It may involve in the etiology and clinicalcourse of CHD as a risk factor.